Cagrilintide for Weight Loss CAS:1415456-99-3
Basic Info.

Description:

Cagrilintide is under development for the treatment of obesity and type 2 diabetes. The drug candidate is administered as a once-daily and once-weekly subcutaneous formulation.

It is a long-acting amylin analogue. Amylin is co-located with insu in secretory granules and co-secreted with insu by pancreatic beta cells in response to food intake. 

Cagrilintide is a long-acting amylin analogue, currently at the forefront of peptide research due to its rather interesting potential beneficial effect in individuals with diabetes. But what’s so special about amylin? Well, amylin is another peptide hormone, co-secreted with insulin, which inhibits food intake, delays gastric emptying, and, most importantly, reduces blood glucose levels. 

Back to cagrilintide… it was originally developed to improve on the initial amylin analogue called pramlintide. The problem with pramlintide is its short half-life and undesired side effects.

Cagrilintide was (and still is being) developed to alter the half-life, potency and stability of pramlintide, and other amylin analogues.Since, it’s still a relatively new peptide, it still needs to undergo further research so we can make sure its as effective and safe.

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