About NAD+:

NAD+ is found in every cell in your body and is essential for creating cellular energy and maintaining cellular health. Levels of this critical molecule correlate with health status in aging. NAD+ levels decline with age. Despite their central role in cellular functions, the body doesn’t have an endless supply of NAD+. In fact, it decreases with age. NAD+ precursors can be used to increase NAD+ levels in the body. Human clinical trials have demonstrated that precursors to NAD+, including nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), can safely and effectively increase NAD+ levels in the body.

The Nuance of NAD+：

Our current understanding of the importance of NAD+ really began in the 1960s. Using nuclear extracts from hen liver, French scientist Pierre Chambon identified a process called Poly ADP-ribosylation, where NAD+ is broken down into two component parts, one of which (nicotinamide) gets recycled, while the other (ADP-ribose) meets up with a protein. This research formed the foundation of the field of PARPs, or poly (ADP-ribose) polymerases, a group of proteins that rely on NAD+ to function and perform cellular functions. PARPs are similar to another group of proteins called sirtuins in that they both only function in the presence of NAD+.

Scientists often refer to sirtuins as “guardians of the genome” for their role in regulating cellular homeostasis. Homeostasis involves keeping the cell in balance. Sirtuins are a group of proteins that were first discovered in the 1970s but their dependence on NAD+ wasn’t realized until the 1990s. Elysium co-founder and MIT biologist Leonard Guarente identified that SIR2, a sirtuin in yeast, extended the life of the yeast only when it was activated by NAD+.

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