About PE-22-28:

The naturally occurring peptide spadin has a synthetic derivative known as PE-22-28. A peptide produced from sortilin, spadin, is released by the organism. The TREK-1 receptor, which stands for TWIK-related potassium channel, is a two-pore potassium channel linked to neurogenesis and may be a target for depression. A loss of the TREK-1 receptor renders mice immune to depression, according to early research in mice. Sortilin also increases neuronal development and synaptic connectivity, increasing resistance to depression.

Function : Emerging research hints at TREK-1’s pivotal involvement in facilitating muscle responses to mechanical stimulation. Notably, inhibiting TREK-1 seems to enhance muscle contractility, while channel activation is considered to promote muscle relaxation.  Although this facet of the TREK-1 channel is in its early exploratory phase, it is steadily gaining significance. Exploring the contributions of molecules like PE-22-28 to muscle contraction and relaxation holds the promise of unraveling fresh avenues to comprehend the intricacies of muscle physiology

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